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Haemoglobin A2 level in pregnancy.

B Benster, M N Cauchi

Journal of Clinical Pathology

|September 1, 1970

Summary

This summary is machine-generated.

Pregnancy does not significantly alter haemoglobin A2 levels. However, elevated haemoglobin A2 in anemic pregnant patients persists postpartum, indicating potential underlying conditions.

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Area of Science:

Hematology
Obstetrics
Clinical Chemistry

Background:

Haemoglobin A2 (HbA2) is a minor haemoglobin variant.
Elevated HbA2 levels can indicate beta-thalassaemia trait.
Changes in HbA2 during pregnancy require investigation.

Purpose of the Study:

To compare HbA2 levels in pregnant and non-pregnant individuals.
To assess the persistence of elevated HbA2 levels postpartum in anemic patients.

Main Methods:

HbA2 levels were measured in 217 pregnant and 137 non-pregnant women.
A subset of 28 anemic pregnant patients was reassessed six weeks after delivery.

Main Results:

Mean HbA2 levels were similar between pregnant (2.4 +/- 0.8%) and non-pregnant (2.3 +/- 0.6%) groups.

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In anemic patients with elevated HbA2 during pregnancy, levels remained high postpartum.

Conclusions:

Pregnancy does not appear to significantly affect mean HbA2 levels.
Persistently elevated HbA2 in anemic postpartum women suggests underlying conditions like beta-thalassaemia trait warrant further evaluation.