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Peripheral nerve function in chronic liver disease.

K N Seneviratne, O A Peiris

    Journal of Neurology, Neurosurgery, and Psychiatry
    |October 1, 1970
    PubMed
    Summary
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    Chronic liver disease often causes subclinical peripheral nerve dysfunction, particularly affecting the median nerve. Increased nerve excitability during ischemia, linked to potassium permeability changes, explains these findings.

    Area of Science:

    • Neurology
    • Hepatology
    • Clinical Electrophysiology

    Background:

    • Peripheral nerve function is frequently compromised in patients with chronic liver disease.
    • Neurological signs of peripheral nerve damage are often minimal despite underlying pathology.

    Purpose of the Study:

    • To investigate peripheral nerve function in patients with chronic liver disease.
    • To explore the relationship between chronic liver disease and neuropathy.
    • To evaluate hypotheses explaining altered nerve excitability during ischemia.

    Main Methods:

    • Electrophysiological assessment of peripheral nerve function in 50 chronic liver disease patients.
    • Measurement of median nerve sensory evoked potentials and distal sensory latencies.
    • Analysis of sensory nerve excitability changes during ischemia.

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    Main Results:

    • 34 out of 50 patients showed abnormalities in median nerve sensory evoked potentials.
    • Alcohol was not identified as the cause of neuropathy.
    • Seven of 16 patients with normal distal latencies exhibited abnormal sensory nerve excitability during ischemia.

    Conclusions:

    • Chronic liver disease can lead to subclinical peripheral neuropathy.
    • Increased periaxonal diffusion barrier permeability to potassium ions is the most plausible explanation for altered nerve resistance to ischemia.