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Related Experiment Videos

Prostatic contribution to normal serum acid phosphatase.

D Dow, R H Whitaker

    British Medical Journal
    |November 21, 1970
    PubMed
    Summary
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    Serum acid phosphatase levels do not significantly change after prostate removal. Tartrate-labile serum acid phosphatase should not be called "prostatic acid phosphatase."

    Area of Science:

    • Biochemistry
    • Urology
    • Clinical Chemistry

    Background:

    • Serum acid phosphatase is an enzyme found in the body.
    • Tartrate-labile serum acid phosphatase has been historically referred to as
    • prostatic acid phosphatase.

    Purpose of the Study:

    • To investigate the relationship between prostate presence and serum acid phosphatase levels.
    • To determine if tartrate-labile serum acid phosphatase can be exclusively attributed to the prostate.
    • To re-evaluate the upper limit of normal for total serum acid phosphatase.

    Main Methods:

    • Comparison of total and tartrate-labile serum acid phosphatase levels in patients with and without prostates.
    • Measurement of serum acid phosphatase levels in 12 patients before and after cystoprostatectomy.

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    Main Results:

    • Absence of the prostate did not significantly alter serum acid phosphatase levels.
    • A considerable number of patients exhibited marginally elevated total serum acid phosphatase levels.
    • The term
    • prostatic acid phosphatase
    • for tartrate-labile serum acid phosphatase is not justified.

    Conclusions:

    • Serum acid phosphatase levels are not solely dependent on the presence of the prostate.
    • The upper limit of normal for total serum acid phosphatase should be considered 5 K.A.u. to account for marginally raised levels.