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Abstract:
Amineptine is a new compound, derived from the tricyclic antidepressants. Its mechanism of action is principally dopaminergic and to a lesser extent serotoninergic. The following are here reported: The results of trials after a single dose: cerebral electrophysiology. Trials of treatment of depression--monopolar and bipolar,--involutional,--neurotic and reactive,--in chronic schizophrenia. The spectrum of activating antidepressant therapeutic activity of this drug is discussed. Other areas in which amineptine has seemed effective in children and adults are discussed. Finally, general, cardiac, ocular acceptability and tolerability in the elderly are reported, together with an analysis of cases of overdose.