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Glomerular microfibrils in renal disease: a comparative electron microscopic study.

H C Hsu, J Churg

    Kidney International
    |October 1, 1979
    PubMed
    Summary
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    Microfibrils, rarely seen in renal glomeruli, were identified in various glomerular diseases. Their presence correlated with subendothelial widening in kidney tissues.

    Area of Science:

    • Nephrology
    • Pathology
    • Electron Microscopy

    Background:

    • Microfibrils are common in connective tissue but rarely observed in the renal glomerulus.
    • Structurally, microfibrils are fibrotubules (12 nm diameter) with a lucid core and dark periphery.

    Purpose of the Study:

    • To investigate the presence and significance of microfibrils in the renal glomerulus in the context of glomerular diseases.

    Main Methods:

    • High-resolution electron microscopy, including stereo microscopy.
    • Analysis of renal biopsy tissues from patients with various glomerular diseases.

    Main Results:

    • Microfibrils were found under the endothelium of capillary walls and in the mesangium in several glomerular diseases.

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  • Diseases included transplant glomerulopathy, focal segmental glomerulosclerosis (Marfan syndrome-associated), preeclamptic toxemia, hemolytic-uremic syndrome, and malignant hypertension.
  • The quantity of microfibrils correlated with the degree of subendothelial widening.

    • Conclusions:

    • Microfibrils are present in the renal glomerulus in specific disease states characterized by subendothelial changes.
    • Their detection may serve as a diagnostic indicator in conditions like transplant glomerulopathy and focal segmental glomerulosclerosis.