[Experimental study of the hepatotoxic effect of toluol. I. Histological and histochemical studies]

The hepatotoxic effect of the analytically pure toluol and a toluol being used in the Chemical Factory "Tiszai" was investigated. Single toxic- and various subtoxic doses of toluol were administered to male rats of CFY intraperitoneally and subcutaneously. The body weight and the weight of the liver were registered. Histological and histochemical study of the liver have also been carried out. After an acute and subacute toluol intoxication decrease of the PAS-positive and Bestcarmin positive material in the liver and increase of the activity of SDH were observed. The degree of the damage to the hepatic tissue depends on the doses of toluol and on the duration of the administration. It is stressed that a severe damage to the whole liver was not seen in any of the experimental animals. There was not any difference noticed between the lesions caused by the different types of toluol.