Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Colitis induced by Clostridium difficile.

J G Bartlett, T Chang, N S Taylor

    Reviews of Infectious Diseases
    |March 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Joint analysis of BICEP2/keck array and Planck Data.

    Physical review letters·2015
    Same author

    Rapid identification of Clostridium botulinum colonies by in vitro toxicity and antimicrobial susceptibility testing.

    World journal of microbiology & biotechnology·2014
    Same author

    Clostridium difficile infection.

    Current problems in surgery·2013
    Same author

    Albumin reduces the antibacterial activity of polyhexanide-biguanide-based antiseptics against Staphylococcus aureus and MRSA.

    Burns : journal of the International Society for Burn Injuries·2013
    Same author

    Isolation of non-typhoidal Salmonella from a haematopoietic progenitor cell product.

    Transfusion medicine (Oxford, England)·2010
    Same author

    Rapid onset of ulcerative typhlocolitis in B6.129P2-IL10tm1Cgn (IL-10-/-) mice infected with Helicobacter trogontum is associated with decreased colonization by altered Schaedler's flora.

    Infection and immunity·2006

    Clostridium difficile causes antibiotic-associated colitis. A diagnostic toxin in patient stool, neutralized by Clostridium sordellii antitoxin, is linked to this condition, showing promise for vancomycin treatment.

    Area of Science:

    • Microbiology
    • Gastroenterology
    • Infectious Diseases

    Background:

    • Clostridium difficile is a primary cause of antibiotic-associated pseudomembranous colitis.
    • Current diagnostic methods rely on a tissue culture assay detecting a cytopathic toxin.

    Purpose of the Study:

    • To identify the causative agent and diagnostic markers for antibiotic-associated pseudomembranous colitis.
    • To evaluate the efficacy of vancomycin for treating Clostridium difficile infections.

    Main Methods:

    • Detection of cytopathic toxin in stool samples using tissue culture assay.
    • Neutralization of toxin with Clostridium sordellii antitoxin.
    • Antimicrobial susceptibility testing of Clostridium difficile strains.

    Related Experiment Videos

    Main Results:

    • A cytopathic toxin was detected in 42 of 43 patients with antibiotic-associated pseudomembranous colitis.
    • The toxin was also found in 12 of 78 patients with antibiotic-associated diarrhea.
    • Toxin neutralization by C. sordellii antitoxin indicated antigenic cross-reactivity with C. difficile toxin.
    • Clostridium difficile strains showed susceptibility to vancomycin.

    Conclusions:

    • The cytopathic toxin neutralized by C. sordellii antitoxin is a reliable marker for Clostridium difficile-associated colitis.
    • Oral vancomycin shows promising initial results for treating this condition.