[Study of the antidepressive effects of a biological transmethylating agent (S-adenosyl-methione or SAM)]

A research has been made in monotherapy and double blind in order to study the antidepressive effects of S-adenosil-L-methionine (SAMe) on homogeneous groups of patients suffering from relapsing endogenous depression out responding to tryciclique tymoleptiques or suffering from neurotic depression. In this last case the drug in question was being studied against amytriptiline. The antidepressive effects of SAMe have been evident and statistically highly interesting, precocious, free from collateral effects and maniacal rebounds. The sample positive effects were noticed also in those patients not responding to tryclique tymoleptiques. Any biochemical mechanism following the central action of SAMe are being discussed.