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Experimental zinc deficiency in man: effect on spermatogenesis
Transactions of the Association of American Physicians
|January 1, 1979
Summary
Low dietary zinc intake in men can cause low sperm count (oligospermia). This condition is reversible with zinc supplementation, indicating zinc deficiency
Area of Science:
- Reproductive Endocrinology
- Human Nutrition
- Andrology
Background:
- Zinc is an essential trace element crucial for male reproductive health.
- Zinc deficiency can impact sperm production and Leydig cell function.
Purpose of the Study:
- To investigate the effects of dietary zinc restriction on sperm count in adult males.
- To determine if zinc-deficiency-induced oligospermia is reversible.
Main Methods:
- Five male volunteers (51-65 years) had their dietary zinc intake restricted (2.7-5.0 mg/day) for 24-40 weeks.
- Sperm counts and Leydig cell function were monitored.
- Zinc supplementation was administered to assess reversibility.
Main Results:
- Dietary zinc restriction led to induced oligospermia in all subjects.
- Sperm count decreased significantly (P < 0.05) from baseline.
- Oligospermia reversed following zinc supplementation (P < 0.025).
Conclusions:
- Mild zinc deficiency can cause reversible oligospermia in men.
- Oligospermia may serve as a sensitive indicator of zinc deficiency.
- Zinc supplementation can restore sperm count and Leydig cell function.