Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

GABA and hippocampal inhibition.

D R Curtis, D Felix, H McLellan

    British Journal of Pharmacology
    |December 1, 1970
    PubMed
    Summary

    Bicuculline, a GABA antagonist, reduces basket cell inhibition in hippocampal neurons. Strychnine had no effect, suggesting GABA is the inhibitory transmitter released by these cells.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Correction to: Inhibition of cathepsin B by caspase-3 inhibitors blocks programmed cell death in Arabidopsis.

    Cell death and differentiation·2018
    Same author

    Inhibition of cathepsin B by caspase-3 inhibitors blocks programmed cell death in Arabidopsis.

    Cell death and differentiation·2016
    Same author

    The partial primary structure of bovine rhodopsin and its topography in the retinal rod cell disc membrane.

    Neurochemistry international·2010
    Same author

    Dimethoxyaporphine as an antagonist of chemical excitation in the pigeon optic tectum.

    Neuroscience letters·2009
    Same author

    John Carew Eccles 1903-1997.

    Historical records of Australian science·2007
    Same author

    Usefulness of immunohistochemistry in delineating renal spindle cell tumours. A retrospective study of 31 cases.

    Histopathology·2004

    Area of Science:

    • Neuroscience
    • Neurophysiology

    Background:

    • Basket cells in the hippocampus provide inhibition to pyramidal neurons.
    • The specific neurotransmitter responsible for this inhibition is not fully established.

    Purpose of the Study:

    • To investigate the identity of the inhibitory neurotransmitter released by hippocampal basket cells.

    Main Methods:

    • Utilized bicuculline, a specific gamma-aminobutyric acid (GABA) antagonist, to block GABAergic transmission.
    • Administered strychnine, an antagonist for glycine receptors, as a control.

    Main Results:

    • Bicuculline significantly diminished the inhibitory effect of basket cells on hippocampal pyramidal neurons.
    • Strychnine did not alter the basket cell-mediated inhibition.

    Conclusions:

    • The findings strongly suggest that gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter released by hippocampal basket cells.

    Related Experiment Videos