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Sensitivity to chemotherapeutics of Yersinia enterocolitica strains
Abstract:
290 Y. enterocolitica strains were tested as regards their sensitivity to 20 chemotherapeutics. All the strains were isolated from fecal specimens taken from human beings in Czechoslovakia. It should be noted that the strains presented homologous group as they belonged to 3 serological group according to Winblad or IA according to Knapp and Thal, they also belonged to biotype 4 according to Nilehn. It has been found that apart from their homogenicity, they showed quite different patterns of sensitivity to chemotherapeutics. Among them quite a great number of the strains were of high level of resistance to antibiotics. It was not possible to transfer their resistance to the sensitive E. coli K12 strain. All the strains proved to produce betalactamase.
Insights
This study investigated the antibiotic resistance of 290 Yersinia enterocolitica strains from Czechoslovakia. Despite belonging to the same group, strains showed varied resistance patterns, with many exhibiting high-level antibiotic resistance not transferable to E. coli K12.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Yersinia enterocolitica is a significant human pathogen.
- Understanding antimicrobial resistance patterns is crucial for effective treatment.
- Previous research on Y. enterocolitica resistance in Czechoslovakia is limited.
Purpose of the Study:
- To determine the sensitivity of Y. enterocolitica strains to various chemotherapeutics.
- To investigate the prevalence of high-level antibiotic resistance in these strains.
- To assess the transferability of observed resistance.
Main Methods:
- Testing 290 Y. enterocolitica strains isolated from human fecal specimens.
- Evaluating sensitivity to 20 different chemotherapeutics.
- Attempting to transfer resistance to a sensitive Escherichia coli K12 strain.
Main Results:
- All strains belonged to serological group 3 (Winblad) or IA (Knapp and Thal) and biotype 4 (Nilehn).
- Significant variations in chemotherapeutic sensitivity were observed among strains.
- A considerable number of strains displayed high-level antibiotic resistance.
- Antibiotic resistance was not transferable to the E. coli K12 strain.
- All tested strains produced betalactamase.
Conclusions:
- Homologous Y. enterocolitica strains can exhibit diverse antimicrobial resistance profiles.
- The high prevalence of resistance and betalactamase production warrants further investigation.
- Non-transferable resistance suggests potential chromosomal or other non-plasmid-mediated mechanisms.