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Related Experiment Videos

Prostatic antibacterial factor. Identity and significance.

W R Fair, J Couch, N Wehner

    Urology
    |February 1, 1976
    PubMed
    Summary
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    Normal prostatic fluid has antibacterial properties due to zinc. Men with chronic bacterial prostatitis have significantly lower zinc levels in their prostatic fluid, suggesting zinc is crucial for prostate health and preventing infections.

    Area of Science:

    • Urology
    • Microbiology
    • Biochemistry

    Background:

    • Normal human prostatic fluid exhibits significant antibacterial activity.
    • This activity is notably reduced or absent in individuals with chronic bacterial prostatitis.

    Observation:

    • Analysis identified a zinc salt as the primary antibacterial factor in prostatic fluid.
    • Prostatic fluid zinc levels were substantially lower in men with chronic bacterial prostatitis compared to healthy controls.
    • This zinc deficiency was independent of serum zinc levels and unresponsive to oral zinc supplementation.

    Findings:

    • Men with chronic bacterial prostatitis had an average prostatic fluid zinc concentration of 50 µg/mL, while controls averaged 448 µg/mL.
    • There was a distinct separation in zinc levels between the patient and control groups, with no overlap.

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  • Reduced prostatic zinc levels were observed even in cases without current prostatic fluid infection, indicating a potential pre-infectious state.

    • Implications:

    • Zinc deficiency in prostatic fluid may compromise the natural defense against bacterial invasion.
    • Low prostatic zinc levels could be a risk factor for developing chronic bacterial prostatitis and subsequent urinary tract infections.
    • This research highlights the potential role of zinc as an in vivo defense mechanism for the prostate.