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Related Experiment Videos

Dipeptide absorption in cystinuria.

M D Hellier, D Perrett, C D Holdsworth

    British Medical Journal
    |December 26, 1970
    PubMed
    Summary
    This summary is machine-generated.

    Patients with cystinuria can absorb lysine as a dipeptide, even if free lysine absorption is impaired. This suggests oligopeptide absorption explains why malnutrition is uncommon in cystinuria.

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    Area of Science:

    • Gastroenterology
    • Biochemistry
    • Genetics

    Background:

    • Cystinuria is a genetic disorder characterized by defective intestinal and renal transport of dibasic amino acids and cystine.
    • Despite impaired absorption and renal loss, clinical malnutrition is rare in cystinuria patients.

    Purpose of the Study:

    • To investigate the absorption of lysine and the dipeptide glycyl-L-lysine in a patient with cystinuria and a normal subject.
    • To elucidate the mechanism by which cystinuria patients avoid malnutrition.

    Main Methods:

    • A perfusion technique was employed to study amino acid and dipeptide absorption.
    • Comparative analysis was performed between a cystinuric patient and a healthy control.

    Main Results:

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    • The cystinuric patient showed impaired absorption of free lysine but effectively absorbed glycyl-L-lysine.
    • The normal subject demonstrated good absorption of both free lysine and glycyl-L-lysine.

    Conclusions:

    • Absorption of dibasic amino acids like lysine may occur via oligopeptide transport in cystinuria.
    • Oligopeptide absorption is a potential compensatory mechanism preventing malnutrition in cystinuria.