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Complex formation between selenium and methylmercury.

L Magos, M Webb, A R Hudson

    Chemico-Biological Interactions
    |December 1, 1979
    PubMed
    Summary
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    Methylmercury forms an unstable complex with selenium compounds, such as selenite and hydrogen selenide, under physiological conditions. This methylmercury-selenium complex can be extracted into benzene, indicating its chemical properties and potential biological implications.

    Area of Science:

    • Biochemistry
    • Environmental Chemistry
    • Toxicology

    Background:

    • Methylmercury is a potent neurotoxin with significant environmental and health implications.
    • Understanding the chemical interactions of methylmercury is crucial for assessing its toxicity and developing mitigation strategies.

    Purpose of the Study:

    • To investigate the chemical complex formed between methylmercury and selenium compounds.
    • To characterize the stability and extractability of this methylmercury-selenium complex.

    Main Methods:

    • Incubation of methylmercury with selenite in rat erythrocytes at 37°C and pH 7.0.
    • Extraction of the resulting complex into benzene.
    • Reaction of methylmercury with hydrogen selenide at pH 7.0 in the absence of erythrocytes.

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    Main Results:

    • An unstable 2:1 complex of methylmercury and selenium was formed and extracted into benzene.
    • The complex, potentially bis-methylmercury selenide, was also formed when methylmercury reacted with hydrogen selenide.
    • The formation of the complex was observed under conditions mimicking physiological environments.

    Conclusions:

    • Methylmercury readily forms a complex with selenium compounds under physiological conditions.
    • This complex exhibits properties that allow for its extraction, suggesting potential pathways for methylmercury transport or transformation.
    • The findings contribute to understanding methylmercury's biogeochemistry and toxicological behavior.