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Influence of oestrogen on thyroid function in the ewe.

The Journal of Physiology

|February 1, 1970

Summary

Oestrogen does not appear to activate thyroid function in ewes, despite thyroid activation observed during oestrus. This study investigated the relationship between oestrogen and thyroid activity in sheep.

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Area of Science:

Reproductive Endocrinology
Thyroid Physiology

Background:

Thyroid activation is observed during oestrus in several species.
This activation may be linked to concurrent oestrogen secretion.

Purpose of the Study:

To investigate the relationship between oestrogen administration and thyroid activity in ewes.
To determine if oestrogen is responsible for thyroid activation during oestrus.

Main Methods:

Measuring thyroid (131)I release rate and plasma protein-bound (131)I concentration.
Analyzing plasma protein-bound (125)I from thyroid vein blood in ewes with exteriorized thyroid glands.
Administering oestrone or oestradiol dibenzoate to various groups of ewes.

Main Results:

No evidence of thyroid activation by oestrogen was found in any experimental group.
This included immature, adult cyclic, anoestrous, and ovariectomized ewes.

Conclusions:

Oestrogen is unlikely to be the cause of thyroid activation observed in normal oestrous ewes.
The findings suggest an alternative mechanism for thyroid activation during oestrus.

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