Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Cardiovascular function in young lambs during summit metabolism.

G Alexander, D Williams

The Journal of Physiology

|May 1, 1970

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Developing and testing a system to improve the quality of heparin anticoagulation in patients with acute cardiac syndromes.

The American journal of cardiology·1998

Same author

Ligand binding to the (1 --> 3)-beta-D-glucan receptor stimulates NFkappaB activation, but not apoptosis in U937 cells.

Biochemical and biophysical research communications·1998

Same author

Health care for the school-age child.

Annual review of nursing research·1998

Same author

Antiproliferative mechanism of action of cryptophycin-52: kinetic stabilization of microtubule dynamics by high-affinity binding to microtubule ends.

Proceedings of the National Academy of Sciences of the United States of America·1998

Same author

Differential regulation of the interleukin-12 receptor during the innate immune response to Leishmania major.

Infection and immunity·1998

Same author

Hospital-wide restriction of clindamycin: effect on the incidence of Clostridium difficile-associated diarrhea and cost.

Annals of internal medicine·1998

Same journal

Smooth muscle cell polycystin 1 (PKD1) is dispensable for physiological regulation of arterial contractility.

The Journal of physiology·2026

Same journal

Protein synthesis in collagenous and non-collagenous fractions of human patellar tendon: Influence of tendinopathy and short-term exercise.

The Journal of physiology·2026

Same journal

Who are you, ketamine? Good, evil, or dose- and context-dependent?

The Journal of physiology·2026

Same journal

Nuances in explaining the blunted erythropoietic response at altitude following recombinant human erythropoietin treatment at sea level.

The Journal of physiology·2026

Same journal

Sex-dependent responses to glucagon agonist therapies in obesity: Mechanistic insights and broader pharmacological implications.

The Journal of physiology·2026

Same journal

Brain sparing in fetal growth restriction: The double-edged sword of fetal hypoxaemia.

The Journal of physiology·2026

See all related articles

Lambs exhibit significantly higher cardiac output during summit metabolism. Thermogenic tissues, like brown fat, are crucial for regulating this metabolic response in young lambs.

Area of Science:

Neonatal physiology
Cardiovascular adaptation
Metabolic regulation

Background:

Newborn lambs experience significant physiological challenges in cold environments.
Understanding thermogenesis and cardiovascular function is critical for neonatal survival.

Purpose of the Study:

To investigate cardiac output and shunting in newborn lambs during summit metabolism.
To determine the relationship between cardiovascular parameters and thermogenic responses.

Main Methods:

Utilized Fick and dye dilution methods to measure cardiac output in lambs.
Assessed oxygen consumption and saturation in thermogenic tissues.
Monitored shunts through the foramen ovale and ductus arteriosus.

Main Results:

Related Experiment Videos

Cardiac output was 50-100% higher during summit metabolism compared to thermoneutral conditions.
Thermogenic tissues (muscle, brown fat) extracted ~80% of oxygen.
Right-to-left foramen ovale shunts were common in neonates, decreasing with age.
Left-to-right ductus arteriosus shunts were observed in cold-exposed lambs.

Conclusions:

Variability in lamb summit metabolism is not solely explained by cardiovascular factors.
Quantity and efficiency of thermogenic tissues likely limit summit metabolism.
Cardiovascular adjustments play a role but are not the primary drivers of metabolic variability.