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Related Experiment Videos

Thyroxine utilization in the new-born lamb.

P W Nathanielsz

    The Journal of Physiology
    |November 1, 1970
    PubMed
    Summary
    This summary is machine-generated.

    Newborn lamb thyroid function shows high plasma thyroxine levels shortly after birth, decreasing significantly in the first two weeks. Thyroxine utilization is high initially, then stabilizes, offering insights into neonatal thyroid regulation.

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    Area of Science:

    • Endocrinology
    • Neonatal Physiology
    • Comparative Mammalian Studies

    Background:

    • The fetal pituitary-thyroid axis is functional before birth in mammals.
    • Limited data exists on pre- and immediate post-natal thyroid function levels.

    Purpose of the Study:

    • To investigate plasma thyroxine levels, thyroxine pool, and utilization rates in newborn lambs from birth to 39 days.
    • To understand the dynamics of thyroid function in the early neonatal period.

    Main Methods:

    • Plasma thyroxine levels were measured in Welsh mountain lambs from birth to 39 days.
    • Thyroxine utilization rates were assessed in relation to body weight.
    • Data was compared with newborn calf thyroxine utilization.

    Main Results:

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    • Plasma thyroxine levels were highest within the first hour post-birth (18.2 mug/100 ml), declining to a minimum (5.1 mug/100 ml) by days 11-12.
    • Thyroxine utilization rate was high in absolute terms and per unit body weight during the first four days post-birth.
    • Utilization rate per kilogram remained relatively constant from day 10 to 39.

    Conclusions:

    • Neonatal lamb thyroid function exhibits distinct early post-natal changes in thyroxine levels and utilization.
    • These findings contribute to understanding the transition from fetal to neonatal thyroid regulation.
    • Comparative analysis with calves highlights species-specific adaptations in neonatal thyroid physiology.