Jove
Visualize
Contact Us

Related Experiment Videos

Intrafollicular amyloid in primary hyperparathyroidism.

P W Leedham, D J Pollock

    Journal of Clinical Pathology
    |December 1, 1970
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The value of biochemical tests in the interpretation of jaundice.

    The Medical journal of Australia·2010
    Same author

    Bladder metastasis from renal cell carcinoma.

    British journal of urology·1997
    Same author

    Symptomatic vitamin E deficiency diagnosed after histological recognition of myometrial lipofuscinosis.

    Lancet (London, England)·1995
    Same author

    Pathology of the liver in leukaemia and lymphoma. A study of 110 autopsies.

    Histopathology·1995
    Same author

    Design of a microwave system for endoscopy: an experimental study of energy, tissue contact, and hemostatic efficacy.

    Gastroenterology·1993
    Same author

    Crohn's disease in Bangladeshis and Europeans in Britain: an epidemiological comparison in Tower Hamlets.

    Postgraduate medical journal·1992
    Same journal

    Measurement of microinvasive breast carcinoma in the 6th edition WHO Classification: risk of overstaging and clinical implications.

    Journal of clinical pathology·2026
    Same journal

    Development and internal validation of a multifactorial risk model for predicting disease-free survival in oral squamous cell carcinoma.

    Journal of clinical pathology·2026
    Same journal

    HER2-low as a unique subgroup in breast cancer: insights from neoadjuvant chemotherapy response and survival analysis.

    Journal of clinical pathology·2026
    Same journal

    Polyp-forming Dieulafoy lesion of the rectum.

    Journal of clinical pathology·2026
    Same journal

    Defining biochemical, pathological and molecular factors prognostic in terms of disease control and survival in high-grade extremity soft tissue sarcoma: a scoping review.

    Journal of clinical pathology·2026
    Same journal

    MILGDF: a multi-task, instance-level supervised model for oral squamous cell carcinoma integrating local-global attention and dynamic decision fusion.

    Journal of clinical pathology·2026
    See all related articles
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies

    Amyloid deposits were found in the parathyroid glands of nine patients with primary hyperparathyroidism. These deposits may indicate the secretion of a peptide hormone similar to calcitonin.

    Area of Science:

    • Endocrinology
    • Histopathology
    • Oncology

    Background:

    • Primary hyperparathyroidism is a common endocrine disorder.
    • Amyloidosis is characterized by the deposition of amyloid proteins in various tissues.
    • The association between parathyroid pathology and amyloid deposits requires further investigation.

    Purpose of the Study:

    • To investigate the presence and significance of local amyloid deposits in parathyroid glands from patients with primary hyperparathyroidism.
    • To explore potential correlations between amyloid deposits and clinical features, such as pluriglandular adenomatosis and systemic amyloidosis.

    Main Methods:

    • Histological review of parathyroid tissue from 88 cases of primary hyperparathyroidism.
    • Analysis of case histories for associations with pluriglandular adenomatosis and systemic amyloidosis.

    Related Experiment Videos

    Main Results:

    • Characteristic intrafollicular amyloid deposits were identified in nine cases (10.2%).
    • Seven of these nine cases had suspected or proven pluriglandular adenomatosis.
    • No correlation was found between parathyroid amyloid deposits and systemic primary or secondary amyloidosis.

    Conclusions:

    • Amyloid deposits in parathyroid glands may serve as a marker for the secretion of a peptide closely related to calcitonin.
    • The findings suggest a potential link between parathyroid amyloid, pluriglandular syndrome, and peptide hormone secretion, particularly concerning calcitonin.
    • Further research is warranted to elucidate the precise role and implications of amyloid in the context of primary hyperparathyroidism and related endocrine conditions.