Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neutrophil granules: A review.

D F Bainton

    The American Journal of Medical Technology
    |January 1, 1976
    PubMed
    Summary

    Neutrophilic polymorphonuclear leukocyte (PMN) granules store antibacterial agents. This study challenges the traditional view that azurophil granules transform into specific granules, presenting new data on PMN granule formation and content.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Retraction.

    American journal of respiratory and critical care medicine·2000
    Same author

    Retraction.

    American journal of respiratory and critical care medicine·2000
    Same author

    Distinct granule populations in human neutrophils and lysosomal organelles identified by immuno-electron microscopy.

    Journal of immunological methods·2000
    Same author

    Glycoprotein V-deficient platelets have undiminished thrombin responsiveness and Do not exhibit a Bernard-Soulier phenotype.

    Blood·1999
    Same author

    Cysteine protease inhibitors alter Golgi complex ultrastructure and function in Trypanosoma cruzi.

    Journal of cell science·1998
    Same author

    Azurophilic granules of human neutrophilic leukocytes are deficient in lysosome-associated membrane proteins but retain the mannose 6-phosphate recognition marker.

    Blood·1998

    Area of Science:

    • Hematology
    • Cell Biology
    • Immunology

    Background:

    • Leukocyte granules are crucial for identifying white blood cells.
    • Neutrophilic polymorphonuclear leukocyte (PMN) granules contain antibacterial agents and lysosomal enzymes for microbial digestion.
    • The established understanding involves azurophil granules transforming into specific granules.

    Purpose of the Study:

    • To present novel data on the formation and chemical composition of PMN granules.
    • To challenge the conventional model of azurophil granule maturation into specific granules.

    Main Methods:

    • Analysis of PMN granule formation.
    • Investigation of PMN granule chemical content.

    Main Results:

    • New insights into the origin and composition of PMN granules.
    • Evidence contradicting the direct transformation of azurophil granules into specific granules.

    Conclusions:

    • The traditional view of PMN granule development requires re-evaluation.
    • Further research is needed to elucidate the precise mechanisms of PMN granule formation and heterogeneity.

    Related Experiment Videos