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Related Experiment Videos

Glucagon in experimental intussusception.

G M Haase, E T Boles

    Journal of Pediatric Surgery
    |December 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Glucagon did not improve the success rate of hydrostatic reduction for ileocolic intussusception in puppies. However, it did facilitate easier reductions and faster vascular supply restoration in successful cases.

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    Area of Science:

    • Veterinary Surgery
    • Gastroenterology
    • Pediatric Surgery

    Background:

    • Intussusception is a common surgical emergency in both human and veterinary pediatrics.
    • Hydrostatic reduction is a less invasive treatment option for intussusception.
    • Glucagon's potential role in facilitating reduction warrants further investigation.

    Purpose of the Study:

    • To evaluate the efficacy of glucagon in improving the success rate of hydrostatic reduction for ileocolic intussusception in puppies.
    • To assess the impact of glucagon on the ease of reduction and postoperative vascular supply restoration.

    Main Methods:

    • A prospective, double-blind study was conducted on 69 puppies with induced ileocolic intussusception.
    • Hydrostatic reduction attempts were performed 18–60 hours post-induction.

    Related Experiment Videos

  • Animals received either glucagon or a placebo, with outcomes assessed for reduction rate, ease of reduction, and vascular supply.

    • Main Results:

    • The overall hydrostatic reduction rate was 70%, with no significant difference between the glucagon and placebo groups.
    • Gangrenous intussusceptions were not reducible by hydrostatic pressure, regardless of glucagon administration.
    • Glucagon significantly facilitated easier reductions and promoted earlier restoration of normal vascular supply in successfully reduced cases.

    Conclusions:

    • Glucagon does not enhance the overall success rate of hydrostatic reduction for canine ileocolic intussusception.
    • Glucagon may be beneficial in improving the procedural ease and hastening vascular recovery following successful hydrostatic reduction.