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Multiple genitourinary abnormalities in females with unilateral renal agenesis: three cases
Insights
Unilateral renal agenesis (URA) affects children, with most females experiencing genitourinary issues later in life. Early investigation before puberty is recommended to manage potential complications in these patients.
Area of Science:
- Pediatric Nephrology
- Urology
- Medical Embryology
Background:
- Unilateral renal agenesis (URA) is a congenital condition requiring lifelong monitoring due to potential complications.
- Established protocols emphasize close follow-up for all patients diagnosed with URA.
Observation:
- Embryologic studies and clinical reports indicate that up to 89% of females with URA have associated genitourinary abnormalities.
- These abnormalities often manifest during puberty or pregnancy, posing significant health risks.
Findings:
- Current identification methods can detect over 75% of infants and children with URA.
- A case series of three teenage females with URA highlights severe complications arising during adolescence.
Implications:
- The findings advocate for aggressive, prepubertal investigation in patients with URA.
- Early detection and management of genitourinary abnormalities in females with URA can prevent serious health issues.
Abstract:
We have the means to identify over 75% of infants and children with unilateral renal agenesis. It has been established that all patients with unilateral renal agenesis must be followed closely because of problems with the remaining kidney and other anomalies. It is apparent from embryologic studies and numerous reports that up to 89% of females with unilateral renal agenesis are likely to have significant accompanying genitourinary abnormalities. Most of these patients' genital problems occur at the time of puberty or pregnancy. Because of our experience with three teenage females who had unilateral renal agenesis and subsequent serious problems, we wish to advocate a prepubertal aggressive investigation.