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The complement system in host defense and inflammation.

Reviews of Infectious Diseases

|May 1, 1979

Summary

This summary is machine-generated.

The complement system is crucial for host defense and inflammation. While deficiencies are rare, understanding complement activation is key to predicting disease and developing future therapies for various illnesses.

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Area of Science:

Immunology
Host Defense Mechanisms
Inflammation Biology

Background:

The complement system is a critical component of innate immunity.
It plays a dual role in host defense and inflammation.
Understanding complement's function is vital for comprehending various disease states.

Purpose of the Study:

To review the significant role of the complement system in host defense and inflammation.
To discuss complement deficiency states and their clinical manifestations.
To explore the involvement of complement in a wide range of illnesses.

Main Methods:

Review of existing literature on complement biology and activation pathways.
Analysis of clinical signs and symptoms associated with complement deficiencies.

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Discussion of complement's role in disease pathogenesis, including inflammation and tissue damage.

Main Results:

Complement is essential for host defense against pathogens.
Complement activation, even when functioning normally, can cause inflammation and tissue damage under abnormal circumstances (e.g., antigen-antibody complex deposition).
Current therapeutic options for controlling complement activation in humans are limited.

Conclusions:

Complement plays a major role in host defense and inflammation.
Clinical manifestations of complement deficiencies can be predicted based on complement's biological activities.
Further research is needed to understand complement's contribution to specific clinical illnesses and host defense against microorganisms, and to develop effective therapeutic interventions.