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Using Zebrafish Models of Human Influenza A Virus Infections to Screen Antiviral Drugs and Characterize Host Immune Cell Responses
Published on: January 20, 2017
Maxwell Finland lecture: the influenza viruses and the human respiratory tract
Abstract:
This paper has reviewed evidence concerning the changes brought about in the structure and function of the lower airways by influenza virus infections. Disposal of inhaled bacteria is believed to be hindered by the mechanical damage to the epithelium of the respiratory tract caused by the virus infection, and phagocytosis is inhibited as well. Alteration in the ventilation, particularly of the peripheral small airways, which has been found in previously healthy persons during and after influenza, may add to the obstruction of the airways in those with chronic bronchitis and emphysema during influenza and may be important in the genesis of these disorders. The immunological defense of the respiratory tract against the influenza viruses has been discussed briefly with reference to the best available means of enhancing this defense, particularly in individuals with chronic pulmonary disease.
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