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[Antitussive effect of amphetamine].

A Tosar, J Marco, S González Barón

    Revista De Medicina De La Universidad De Navarra
    |September 1, 1979
    PubMed
    Summary
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    Amphetamine significantly reduces coughing and respiratory delays in dogs. This study shows a notable decrease in these responses at a dosage of 1 mg/kg, highlighting its potential effects on respiratory reflexes.

    Area of Science:

    • Pharmacology
    • Neuroscience
    • Respiratory Physiology

    Context:

    • Investigating the physiological effects of amphetamine on respiratory reflexes.
    • Examining the mechanisms underlying cough and respiratory delay.
    • Utilizing canine models for preclinical research on drug effects.

    Purpose:

    • To determine the efficacy of amphetamine in suppressing cough reflexes induced by tracheal excitation.
    • To assess the impact of amphetamine on delaying respiratory responses triggered by laryngeal excitation.
    • To quantify the dose-dependent effects of amphetamine on these specific respiratory actions.

    Summary:

    • Experimental investigations in dogs demonstrated that amphetamine administration significantly decreases both cough responses to tracheal excitation and respiratory delays from laryngeal excitation.

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  • A notable reduction in these physiological responses was observed at a dosage of 1 mg/kg.
  • These findings suggest a potent inhibitory effect of amphetamine on specific airway reflexes.

    • Impact:

    • Provides crucial data on the antitussive and respiratory-modulating properties of amphetamine.
    • Informs potential therapeutic applications or side effect considerations of amphetamine-like compounds.
    • Contributes to the understanding of central and peripheral mechanisms controlling cough and respiration.