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[Actinomycin D: toxic effects with special reference to hepatic injury]
Summary
Actinomycin D can cause liver dysfunction, particularly after recent liver irradiation. This toxic effect was observed in two pediatric cancer patients treated with Actinomycin D.
Area of Science:
- Pharmacology
- Hepatology
- Pediatric Oncology
Background:
- Actinomycin D is an antineoplastic antibiotic used in cancer treatment.
- Hepatic irradiation can predispose the liver to toxic effects from certain drugs.
- Understanding drug toxicity is crucial for patient safety in oncology.