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Related Experiment Videos

Cutaneous basophil hypersensitivity. II. A light and electron microscopic description.

H F Dvorak, A M Dvorak, B A Simpson

    The Journal of Experimental Medicine
    |September 1, 1970
    PubMed
    Summary

    Researchers identified a distinct skin reaction, cutaneous basophil hypersensitivity (CBH), characterized by basophil infiltration. This early-stage immune response differs from typical delayed hypersensitivity and antibody-mediated reactions.

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    Area of Science:

    • Immunology
    • Dermatology
    • Cell Biology

    Background:

    • Delayed hypersensitivity and antibody-mediated reactions are well-characterized immune responses.
    • Early sensitization can elicit unique skin reactions with distinct morphologies.

    Purpose of the Study:

    • To characterize the morphology and cellular infiltrate of early-onset erythematous skin reactions in guinea pigs.
    • To differentiate these early reactions from established hypersensitivity types and propose a new designation.

    Main Methods:

    • Sensitization of guinea pigs with protein antigens (azobenzenearsonate-protein conjugates or protein antigens in various adjuvants).
    • Elicitation of skin reactions at early and late intervals post-sensitization.
    • Morphological analysis of dermal infiltrates using microscopy.

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    Main Results:

    • Early reactions showed massive dermal infiltration with basophilic leukocytes and various mononuclear cells.
    • This distinct morphology was termed cutaneous basophil hypersensitivity (CBH), differing from Jones-Mote hypersensitivity.
    • Basophils often underwent degeneration and phagocytosis by macrophages, with no evidence of histamine-like effects.

    Conclusions:

    • Cutaneous basophil hypersensitivity (CBH) is a distinct immunologic and morphologic entity.
    • CBH occurs early in sensitization with protein antigens, regardless of the vehicle.
    • The precise function of basophils in CBH and its pathogenic mechanisms require further investigation.