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Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5
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Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5

Published on: April 26, 2019

Small intestinal changes in enterocolitis complicating Hirschsprung's disease

D Branski, E Lebenthal

    Journal of Clinical Gastroenterology
    |September 1, 1979
    PubMed

    Insights

    Hirschsprung's disease can cause severe infant diarrhea due to small bowel damage. Early treatment of enterocolitis, including nutritional support, is crucial for survival.

    Area of Science:

    • Pediatric Surgery
    • Gastroenterology
    • Neonatology

    Background:

    • Hirschsprung's disease is a common cause of bowel obstruction in children.
    • Untreated enterocolitis, a complication of Hirschsprung's disease, carries significant mortality risk.

    Observation:

    • Two infants presented with intractable diarrhea of infancy.
    • The diarrhea was secondary to Hirschsprung's disease.

    Findings:

    • Mucosal damage in the small bowel is a key factor.
    • Disaccharidase deficiency contributes significantly to the complication.

    Implications:

    • Prompt management of enterocolitis is vital.
    • Parenteral alimentation should be initiated early upon complication detection.

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