Coagulation of serum by glutaraldehyde

A semiquantitative method for the determination of the gamma-globulin in human serum was developed based on the observation that dilute glutaraldehyde solutions at serum pH first attack the most basic serum proteins, leading to a polymer (clot) consisting mainly of gamma-globulins. The clotting ability of serum by glutaraldehyde thus caould be used as an indicator of the gamma-globulin concentration.