[Genetic control of spontaneous resistance to murine adenocarcinoma (ADK-lt)]

The genetic control of spontaneous resistance by virgin mice towards a mammary adenocarcinoma of BALB/c mice origin was studied in F1 hybrid mice produced by crossing BALB/c females with males of different haplotype from BALB, A, or B10 strain. The findings obtained show that the intensity of natural resistance in vivo is not under an unigenic control but is the result of multiple interactions among genes located both inside or outside the major histocompatibility complex.