Thymidylate synthetase from amethopterin-resistant Lactobacillus casei

Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug.

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Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.

The Journal of biological chemistry·2001

Cation binding and thermostability of FTHFS monovalent cation binding sites and thermostability of N10-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Biochemistry·2000

Catalytic cysteine of thymidylate synthase is activated upon substrate binding.

Biochemistry·2000

The crystal structure of N(10)-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Biochemistry·2000

Kinetic studies on drug-resistant variants of Escherichia coli thymidylate synthase: functional effects of amino acid substitutions at residue 4.

Archives of biochemistry and biophysics·1999

Analysis of the Atypical Temperature Dependence and Conformational Changes During Turnover of a Lactobacillus Chlorogenic Acid Esterase.

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Related Experiment Videos

Thymidylate synthetase from amethopterin-resistant Lactobacillus casei

Related Concept Videos

Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug.

Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.

Cation binding and thermostability of FTHFS monovalent cation binding sites and thermostability of N10-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Catalytic cysteine of thymidylate synthase is activated upon substrate binding.

The crystal structure of N(10)-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Kinetic studies on drug-resistant variants of Escherichia coli thymidylate synthase: functional effects of amino acid substitutions at residue 4.

Analysis of the Atypical Temperature Dependence and Conformational Changes During Turnover of a Lactobacillus Chlorogenic Acid Esterase.

Conformational and Functional Divergence of RnpA Protein Subfamilies in Bacterial Ribonucleoprotein RNase P.

Hyperfusogenic Mutations Destabilize the Postfusion Six-Helix Bundle of the Measles Virus Fusion Glycoprotein.

Membrane Models and the Pursuit of Coherence.

Combinatorial Residue Recognition in SsTx-4 Inhibition of the Kir4.1/5.1 Channel.

Biochemical Characterization of ABHD14A, an Outlying Member of the Metabolic Serine Hydrolase Family.

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Dermatofibrosarcoma protuberans mimicking hemorrhoids: a rare case report.

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Case Report: Phosphaturic mesenchymal tumor of the scapula without calcification: a potential diagnostic pitfall.

Pseudomyogenic hemangioendothelioma of the thoracolumbar spine: A case-based review of a rare cause of vertebral collapse and neurological deficit.

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Thymidylate synthetase from amethopterin-resistant Lactobacillus casei

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