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Related Experiment Videos

Pulmonary compliance: alteration during infection.

N L Somerson, S B Kontras, J D Pollack

    Science (New York, N.Y.)
    |January 8, 1971
    PubMed
    Summary

    Infection with Mycoplasma pulmonis increases lung surface forces, making rat lungs harder to inflate. This suggests the lung surfactant system is disrupted by the infection.

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    Area of Science:

    • Pulmonary Medicine
    • Microbiology
    • Respiratory Physiology

    Background:

    • Mycoplasma pulmonis is a common respiratory pathogen in rodents.
    • Respiratory infections can alter lung mechanics and gas exchange.
    • The lung surfactant system is crucial for maintaining alveolar stability and reducing surface tension.

    Purpose of the Study:

    • To investigate the effects of Mycoplasma pulmonis infection on lung mechanics.
    • To determine if infection alters pulmonary surface forces.
    • To assess the integrity of the lung surfactant system in infected lungs.

    Main Methods:

    • Excised rat lungs were inflated with air and saline.
    • Lung compliance was measured in infected and control groups.
    • Differences in inflation pressure and volume were analyzed.

    Main Results:

    • Lungs from Mycoplasma pulmonis-infected rats were significantly harder to inflate with air compared to controls.
    • No significant differences in inflation were observed when using saline.
    • This indicates an increase in surface forces within the infected lungs.

    Conclusions:

    • Mycoplasma pulmonis infection impairs lung function by increasing surface forces.
    • The findings suggest a disruption of the lung surfactant system.
    • Further research is needed to elucidate the precise mechanisms of surfactant dysfunction.

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