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Related Concept Videos

Autoregulation of Blood Flow01:17

Autoregulation of Blood Flow

Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
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Related Experiment Video

Updated: Jul 8, 2026

Non-invasive Assessment of Microvascular and Endothelial Function
05:41

Non-invasive Assessment of Microvascular and Endothelial Function

Published on: January 29, 2013

Skin capillary blood flow in scleroderma.

E C LeRoy, J A Downey, P J Cannon

    The Journal of Clinical Investigation
    |April 1, 1971
    PubMed
    Summary
    This summary is machine-generated.

    Scleroderma patients exhibit significantly reduced skin blood flow during cooling, suggesting circulatory impairment. This study highlights potential therapeutic targets for managing scleroderma symptoms.

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    07:18

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    Published on: February 18, 2022

    Area of Science:

    • Dermatology
    • Vascular Biology
    • Medical Physics

    Background:

    • Scleroderma is a connective tissue disease characterized by skin thickening and vascular abnormalities.
    • Assessing cutaneous microcirculation is crucial for understanding scleroderma pathogenesis and progression.

    Purpose of the Study:

    • To quantify skin blood flow in scleroderma patients compared to healthy controls.
    • To investigate the impact of cooling and warming on cutaneous circulation in scleroderma.
    • To explore the potential of xenon-133 clearance as a method for evaluating scleroderma-related vascular dysfunction.

    Main Methods:

    • Intracutaneous injection of radioactive xenon (133Xe) for clearance measurement.
    • Controlled cooling (18°C) and reflex warming (waterbath) protocols.
    • Comparison of 133Xe clearance rate constants and calculated blood flow between scleroderma patients and controls.

    Main Results:

    • Scleroderma patients showed significantly lower 133Xe clearance rates and blood flow (2.9 ml/100g/min) compared to controls (16.4 ml/100g/min) upon cooling (P < 0.005).
    • After reflex warming, clearance normalized, but skin temperatures remained lower in scleroderma patients, indicating dissociation between blood flow and temperature regulation.
    • Guanethidine treatment improved 133Xe clearance in some scleroderma patients, suggesting a role for sympathetic vasoconstriction.

    Conclusions:

    • Diminished skin blood flow on cooling in scleroderma is likely due to reversible circulatory interruption.
    • Abnormal thermal regulation or selective vasoconstriction may contribute to scleroderma's vascular manifestations.
    • 133Xe clearance is a valuable tool for quantitative assessment of skin blood flow and therapeutic evaluation in scleroderma.