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5-fluorocytosine and urinary candidiasis
British Medical Journal
|March 13, 1971
Summary
This study shows that 5-fluorocytosine is effective for treating urinary candidiasis. The drug demonstrated no toxicity in patients at daily dosages of 2 to 5 grams.
Area of Science:
- Medical Mycology
- Pharmacology
- Infectious Diseases
Background:
- Urinary tract infections caused by Candida species (urinary candidiasis) require effective antifungal treatment.
- 5-fluorocytosine is an antifungal agent with known activity against Candida.
Purpose of the Study:
- To evaluate the efficacy and safety of 5-fluorocytosine in patients with urinary candidiasis.
- To monitor serum drug levels and urinary excretion of 5-fluorocytosine.
Main Methods:
- Case study of two patients diagnosed with urinary candidiasis.
- Administration of 5-fluorocytosine at daily dosages ranging from 2 to 5 grams.
- Measurement of serum drug concentrations and analysis of urinary excretion patterns.
Main Results:
- Both patients were successfully treated for urinary candidiasis.
- Serum levels and urinary excretion of 5-fluorocytosine were documented.
- No evidence of drug-related toxicity was observed within the studied dosage range.
Conclusions:
- 5-fluorocytosine is a potentially safe and effective treatment option for urinary candidiasis.
- Further investigation into its pharmacokinetic profile and clinical utility is warranted.