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Intrarenal Injection of Escherichia coli in a Rat Model of Pyelonephritis
Published on: July 18, 2017
Renal lysozyme levels in animals developing Proteus mirabilis-induced pyelonephritis
Applied Microbiology
|February 1, 1971
Summary
Unilateral pyelonephritis increases renal lysozyme activity in both infected and non-infected kidneys. The non-infected kidney consistently showed higher lysozyme levels, but this did not prevent infection.
Area of Science:
- Nephrology
- Immunology
- Microbiology
Background:
- Pyelonephritis is a kidney infection that can lead to renal damage.
- Lysozyme is an enzyme with antimicrobial properties found in renal tissue.
Purpose of the Study:
- To investigate the changes in renal lysozyme activity during experimentally induced unilateral pyelonephritis.
- To compare lysozyme activity between infected and non-infected kidneys.
Main Methods:
- Induction of unilateral pyelonephritis in animals using Proteus mirabilis.
- Measurement of renal lysozyme activity in infected and contralateral kidneys over 17 days.
- Control group with saline puncture to assess trauma effects.
Main Results:
- Both infected kidney (IK) and contralateral non-infected kidney (NIK) showed a biphasic increase in lysozyme activity.
- Lysozyme activity was consistently higher in the NIK compared to the IK.
- Saline-punctured kidneys showed a transient increase, with the non-punctured kidney exhibiting a greater response than the punctured one.
Conclusions:
- Experimental pyelonephritis significantly elevates renal lysozyme activity bilaterally.
- The contralateral kidney exhibits a more pronounced lysozyme response.
- Elevated lysozyme in the non-infected kidney did not confer protection against bacterial infection.
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