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Related Experiment Videos

Uncoupling cell junctions in a glandular epithelium by depolarizing current.

S J Socolar, A L Politoff

    Science (New York, N.Y.)
    |April 30, 1971
    PubMed
    Summary

    Electrical conductance between Chironomus salivary gland border cells decreases reversibly with outward current. This uncoupling correlates with increased conductance in the cell membrane, not the junction.

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    Cell-to-cell channels with two independently regulated gates in series: analysis of junctional conductance modulation by membrane potential, calcium, and pH.

    The Journal of membrane biology·1983

    Area of Science:

    • Cell biology
    • Electrophysiology
    • Ion channel research

    Background:

    • Adjacent cells in Chironomus salivary glands exhibit high electrical conductance.
    • This conductance facilitates intercellular communication and transport.

    Purpose of the Study:

    • To investigate the electrical properties of intercellular junctions between salivary gland border cells.
    • To determine the effect of electrical current on cell-cell conductance and membrane conductance.

    Main Methods:

    • Electrophysiological recordings were performed on Chironomus salivary gland border cells.
    • Electrical current was passed outward and inward through individual cells.
    • Changes in intercellular conductance and cell membrane conductance were measured.

    Main Results:

    • Outward current passage reversibly decreased the high electrical conductance between adjacent border cells.
    • Inward current passage did not significantly affect the intercellular conductance.
    • The observed uncoupling was associated with an electrically induced increase in conductance within the nonjunctional cell membrane.

    Conclusions:

    • Electrical activity can modulate intercellular communication in Chironomus salivary glands.
    • The cell membrane's electrical properties play a role in regulating junctional conductance.
    • These findings suggest a mechanism for dynamic control of cell-cell coupling.

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