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Related Experiment Videos

Phenylbutazone toxicity in ponies.

D H Snow, J A Bogan, T A Douglas

    The Veterinary Record
    |July 14, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Phenylbutazone toxicity in ponies is a significant concern, with oral administration leading to anorexia, edema, and potentially fatal shock. This study highlights the adverse effects of phenylbutazone in equine medicine.

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    Area of Science:

    • Veterinary Medicine
    • Equine Pharmacology
    • Toxicology

    Background:

    • Phenylbutazone is a commonly used non-steroidal anti-inflammatory drug (NSAID) in horses.
    • Its efficacy is well-established, but potential adverse effects require careful monitoring.
    • Understanding phenylbutazone toxicity is crucial for safe clinical application in equine practice.

    Purpose of the Study:

    • To investigate the toxic effects of oral phenylbutazone administration in ponies.
    • To document clinical signs, biochemical changes, and necropsy findings associated with phenylbutazone toxicity.
    • To evaluate the safety of intravenous phenylbutazone administration in a limited number of cases.

    Main Methods:

    • Oral administration of phenylbutazone at approximately 10 mg/kg/day for 7-14 days to eight ponies.

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  • Monitoring of clinical signs, including appetite, demeanor, and physical examination findings.
  • Blood biochemical analysis to assess plasma protein, calcium, and urea concentrations.
  • Necropsy examination of affected animals.
  • Intravenous administration of phenylbutazone (4.0 mg/kg) for seven days in two ponies.

    • Main Results:

    • Seven of eight ponies receiving oral phenylbutazone developed toxicity.
    • Clinical signs included anorexia, depression, and abdominal edema.
    • Biochemical changes indicated water retention (decreased plasma protein and calcium, increased urea).
    • Three ponies died from shock, attributed to submucosal intestinal edema.
    • Oral ulceration was observed in treated animals.
    • One pony receiving intravenous phenylbutazone showed a marked decrease in total plasma protein.

    Conclusions:

    • Oral phenylbutazone at the tested dosage and duration can induce significant toxicity in ponies.
    • The development of shock linked to intestinal edema is a critical adverse event.
    • Phenylbutazone-induced water retention and gastrointestinal ulceration are key toxicological concerns.
    • Further research into safer dosing regimens and alternative treatments is warranted for equine NSAID therapy.