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Platelet aggregation and strenuous exercise.

L Poller, C M Priest, J M Thomson

    The Journal of Physiology
    |March 1, 1971
    PubMed
    Summary
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    Strenuous exercise increases platelet aggregation and accelerates the intrinsic blood clotting system in normal adults. This occurs alongside a rise in fibrinogen, even with enhanced fibrinolysis, confirming platelet sensitivity to clotting changes.

    Area of Science:

    • Physiology
    • Hematology
    • Exercise Science

    Background:

    • Platelet aggregation plays a crucial role in hemostasis and thrombosis.
    • The intrinsic blood clotting system is a complex cascade influencing coagulation.
    • Strenuous physical exercise is known to induce various physiological changes.

    Purpose of the Study:

    • To investigate the effect of strenuous physical exercise on platelet aggregation.
    • To examine the relationship between exercise-induced coagulation changes and platelet response.
    • To assess the impact on fibrinogen levels and fibrinolysis.

    Main Methods:

    • Normal male and female volunteers participated in strenuous physical exercise.
    • Platelet aggregation was measured using the Chandler's tube method.

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  • Parameters of the intrinsic blood clotting system, fibrinogen, and fibrinolysis were monitored.

    • Main Results:

    • Strenuous exercise led to increased platelet aggregation.
    • A concurrent acceleration of the intrinsic blood clotting system was observed.
    • Fibrinogen levels rose despite increased fibrinolysis, indicating a complex hemostatic response.

    Conclusions:

    • The platelet aggregation system is highly sensitive to alterations in the intrinsic clotting mechanism.
    • Physiological stressors like strenuous exercise can trigger accelerated platelet aggregation via the coagulation system.
    • These findings highlight the intricate interplay between exercise, coagulation, and platelet function.