Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Linoleate metabolism in multiple sclerosis.

J Belin, N Pettet, A D Smith

    Journal of Neurology, Neurosurgery, and Psychiatry
    |February 1, 1971
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Dyspepsia on withdrawal of ranitidine in previously asymptomatic volunteers.

    The American journal of gastroenterology·1999
    Same author

    A disulfide-bound HIV-1 V3 loop sequence on the surface of human rhinovirus 14 induces neutralizing responses against HIV-1.

    Biological chemistry·1999
    Same author

    Percutaneous nephrolithotomy with renal angiomyolipomas: a rare challenge.

    Journal of endourology·1999
    Same author

    Complete renal embolization as an alternative to nephrectomy.

    The Journal of urology·1999
    Same author

    Relationship between clinical and radiological diagnostic criteria for Alzheimer's disease and the extent of neuropathology as reflected by 'stages': a prospective study.

    Dementia and geriatric cognitive disorders·1999
    Same author

    The progression of Alzheimer's disease from limbic regions to the neocortex: clinical, radiological and pathological relationships.

    Dementia and geriatric cognitive disorders·1999

    Multiple sclerosis (MS) patients have lower serum linoleate levels. Linoleate supplementation normalized levels in MS patients, indicating no absorption defects and suggesting dietary interventions for MS.

    Area of Science:

    • Biochemistry
    • Neuroscience
    • Nutrition Science

    Background:

    • Patients with multiple sclerosis (MS) exhibit altered serum fatty acid profiles compared to healthy individuals.
    • Previous research suggests a potential difference in linoleate metabolism in MS patients.

    Purpose of the Study:

    • To investigate serum oleate and linoleate levels in multiple sclerosis (MS) patients and healthy controls.
    • To assess the impact of dietary linoleate supplementation on these fatty acid levels in both groups.
    • To evaluate potential intestinal absorption defects of linoleate in the context of MS.

    Main Methods:

    • Serum lipid levels of oleate and linoleate were measured in 14 MS patients and 14 healthy controls.
    • Measurements were taken before, during, and after a five-day period of dietary supplementation with linoleate.

    Related Experiment Videos

  • Linoleate was administered in the form of sunflower seed oil to assess absorption.

    • Main Results:

    • MS patients showed significantly lower serum linoleate percentages (P < 0.01) and higher oleate percentages (P < 0.005) than controls before supplementation.
    • Linoleate supplementation significantly increased serum linoleate and decreased oleate percentages in both MS patients and controls.
    • No evidence of impaired intestinal absorption of linoleate was found, even with high intake.

    Conclusions:

    • MS patients have distinct serum fatty acid profiles characterized by lower linoleate and higher oleate.
    • Dietary linoleate supplementation effectively modulates serum fatty acid levels in MS patients, similar to controls.
    • The findings suggest that impaired absorption is not a factor in the altered fatty acid levels observed in MS.