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Urine concentration in depressive illness.

G G Ellis, A Coppen, A I Glen

    Journal of Neurology, Neurosurgery, and Psychiatry
    |February 1, 1971
    PubMed
    Summary
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    Depressed patients excrete less solute per urine volume compared to controls. This difference was not significant in those recently recovered from depression, suggesting a return towards normal solute excretion.

    Area of Science:

    • Neuroscience and Psychiatry
    • Renal Physiology and Endocrinology

    Background:

    • Affective disorders, such as depression, may involve alterations in body fluid regulation.
    • Previous research suggests potential roles for antidiuretic hormone (ADH) and aldosterone in mood disorders.

    Purpose of the Study:

    • To investigate differences in urine solute and volume excretion between depressed patients and healthy controls.
    • To explore whether solute excretion patterns normalize after recovery from depression.

    Main Methods:

    • Collected 132 urine specimens from 17 depressed patients and 18 controls under mild water deprivation.
    • Measured mean milliosmoles of solute and milliliters of urine excreted per hour for each subject.
    • Compared solute excretion rates between groups, including those recently recovered from depression.

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    Main Results:

    • Depressed patients excreted significantly less solute per unit volume of urine compared to the control group.
    • No significant difference in solute excretion rates was observed between currently depressed patients and those recently recovered.
    • A trend towards normal solute excretion was noted in patients who had recently recovered from depression.

    Conclusions:

    • Altered urine solute concentration may be a physiological marker associated with depression.
    • These findings suggest potential dysregulation in body fluid homeostasis, possibly involving ADH or aldosterone.
    • Solute excretion patterns may approach normality with recovery from depressive episodes.