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Response of the Syrian golden hamster to a nitrosourea amino acid carcinogen
Abstract:
Syrian golden hamsters were treated with N delta-(N-methyl-N-nitrosocarbamoyl)-L-ornithine (MNCO), a nitrosourea amino acid, which has induced a high incidence of breast, kidney and skin neoplasms and a low incidence of pancreatic carcinoma in rats. MNCO induced a few breast and skin carcinomas, and a high incidence of foci of atypical acinar cells and of focal ductular abnormalities in the exocrine pancreas. The latter were similar to lesions observed in rats treated with MNCO. MNCO was less toxic and less effective as a carcinogen in hamster than in the rat.
Insights
N delta-(N-methyl-N-nitrosocarbamoyl)-L-ornithine (MNCO) induced pancreatic abnormalities in hamsters, unlike rats. This carcinogen showed lower toxicity and effectiveness in hamsters compared to rats.
Area of Science:
- Oncology
- Toxicology
- Carcinogenesis
Background:
- Nitrosourea amino acids are investigated for carcinogenic potential.
- N delta-(N-methyl-N-nitrosocarbamoyl)-L-ornithine (MNCO) is a nitrosourea derivative with known carcinogenic effects in rats.
Purpose of the Study:
- To evaluate the carcinogenic effects of MNCO in Syrian golden hamsters.
- To compare the carcinogenicity and toxicity of MNCO in hamsters versus rats.
Main Methods:
- Syrian golden hamsters were administered MNCO.
- Tumor incidence and histopathological changes in various organs, particularly the exocrine pancreas, were assessed.
Main Results:
- MNCO induced a low incidence of breast and skin carcinomas in hamsters.
- A high incidence of atypical acinar cell foci and ductular abnormalities was observed in the hamster pancreas.
- Lesions in hamsters were comparable to those seen in rats, but MNCO exhibited lower toxicity and carcinogenicity in hamsters.
Conclusions:
- MNCO demonstrates carcinogenic activity in Syrian golden hamsters, primarily affecting the exocrine pancreas.
- Hamsters exhibit a different susceptibility profile to MNCO compared to rats, with reduced toxicity and carcinogenicity.