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Bacterial interference as a factor in renal infection.

T E Miller, E Creaghe

    The Journal of Laboratory and Clinical Medicine
    |May 1, 1976
    PubMed
    Summary
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    Bacterial interference prevents mixed Escherichia coli infections in the kidney. Even when introduced together, one E. coli strain often prevents the other from causing renal infection, impacting infection patterns.

    Area of Science:

    • Microbiology
    • Epidemiology
    • Nephrology

    Background:

    • Renal infections, particularly pyelonephritis, are often caused by Escherichia coli.
    • Understanding the factors influencing the establishment and pattern of bacterial infections in the kidney is crucial for public health.
    • The role of bacterial interference in polymicrobial infections remains an area of active investigation.

    Purpose of the Study:

    • To investigate the phenomenon of bacterial interference in the context of renal infections caused by Escherichia coli.
    • To determine if simultaneous introduction of two nephropathogenic E. coli strains leads to mixed infections.
    • To elucidate the mechanisms by which bacterial interference influences the epidemiology of pyelonephritis.

    Main Methods:

    • Utilized two distinct, genetically marked strains of Escherichia coli (E. coli 08 and E. coli 075) isolated from clinical pyelonephritis cases.

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  • Administered bacterial strains via direct inoculation into the kidney and retrograde challenge models in experimental animals.
  • Assessed infection establishment and patterns using differentiated strains based on streptomycin resistance and arabinose utilization markers.

    • Main Results:

    • Simultaneous direct inoculation of E. coli 08 and E. coli 075 into the kidney readily established mixed infections.
    • Retrograde challenge with a mixed E. coli culture predominantly resulted in infection by the E. coli 08 strain alone, indicating interference.
    • Established unilateral E. coli 08 infection prevented subsequent E. coli 075 infection in the same kidney, while contralateral infection occurred.

    Conclusions:

    • Bacterial interference is a significant factor in determining the outcome of renal infections caused by Escherichia coli.
    • Mixed renal infections with E. coli are uncommon, even when strains are equally nephropathogenic and introduced simultaneously.
    • Interference mechanisms within the kidney play a critical role in preventing polymicrobial E. coli pyelonephritis.