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Haemodynamics during partial extracorporeal circulation in the dog
Pflugers Archiv : European Journal of Physiology
|January 17, 1977
Summary
This study on dogs found that partial extracorporeal circulation initially decreased cardiac output and pressure. However, total blood flow returned to normal levels with increased extracorporeal flow, suggesting enhanced venous return.
Area of Science:
- Cardiovascular Physiology
- Extracorporeal Circulation
Background:
- Partial extracorporeal circulation (ECC) is used in medical procedures.
- Understanding circulatory responses during ECC is crucial for patient safety.
Purpose of the Study:
- To investigate circulatory changes in dogs during partial extracorporeal circulation.
- To determine the effects of varying extracorporeal flow rates on hemodynamic parameters.
Main Methods:
- Nine mongrel dogs underwent partial extracorporeal circulation from the right atrium to the carotid and/or femoral artery.
- A membrane oxygenator and roller pump constituted the bypass circuit.
- Measurements included cardiac output, arterial pressure, and right atrial/pulmonary wedge pressures.
Main Results:
- Cardiac output and arterial pressure decreased during bypass.
- Hemodynamic parameters showed minimal changes with increased extracorporeal flow (EF) from 1/10 to 3/4 of control cardiac output.
- Total blood flow equaled control at 1/2 EF and exceeded control at 3/4 EF.
- Right atrial and pulmonary wedge pressures were lower than control.
Conclusions:
- Partial extracorporeal circulation can maintain or enhance total blood flow despite initial decreases in cardiac output.
- Sympathetic stimulation via atrial mechanoreceptors is a likely mechanism for enhanced venous return during ECC.