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Serum dopamine- -hydroxylase: decrease after chemical sympathectomy.

R Weinshilboum, J Axelrod

    Science (New York, N.Y.)
    |September 3, 1971
    PubMed
    Summary
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    Serum dopamine-beta-hydroxylase activity originates partly from sympathetic nerve terminals. Destroying these nerve terminals with 6-hydroxydopamine significantly decreased enzyme levels in rats, confirming this link.

    Area of Science:

    • Neuroscience
    • Biochemistry
    • Pharmacology

    Background:

    • Dopamine-beta-hydroxylase (DBH) is an enzyme crucial for catecholamine synthesis.
    • DBH is found in sympathetic nerves, the adrenal medulla, and serum.

    Purpose of the Study:

    • To investigate the origin of serum dopamine-beta-hydroxylase activity.
    • To determine if sympathetic nerve terminals contribute to circulating DBH levels.

    Main Methods:

    • Administration of 6-hydroxydopamine to rats to selectively destroy sympathetic nerve terminals.
    • Measurement of serum dopamine-beta-hydroxylase activity before and after treatment.
    • Exclusion of adrenal medulla effects and circulating inhibitors as causes for activity changes.

    Main Results:

    Related Experiment Videos

    • Treatment with 6-hydroxydopamine led to a significant decrease in serum DBH activity.
    • This reduction was not attributable to adrenal medulla function or enzyme inhibitors.

    Conclusions:

    • Sympathetic nerve terminals are a significant source of circulating dopamine-beta-hydroxylase.
    • These findings provide evidence for the contribution of peripheral sympathetic nerves to serum DBH levels.