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Nephrotic syndrome in the elderly.

I W Fawcett, P J Hilton, N F Jones

    British Medical Journal
    |May 15, 1971
    PubMed
    Summary
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    Nephrotic syndrome is more common in older adults than previously thought. Minimal change disease is a frequent cause, and elderly patients often respond well to prednisone treatment.

    Area of Science:

    • Nephrology
    • Geriatric Medicine
    • Internal Medicine

    Background:

    • Nephrotic syndrome is often considered rare in elderly populations.
    • However, recent studies indicate a higher prevalence in individuals aged 60 and above.

    Purpose of the Study:

    • To investigate the incidence and histological patterns of nephrotic syndrome in elderly patients.
    • To evaluate the treatment response to prednisone in older adults with minimal change disease.

    Main Methods:

    • Retrospective analysis of 100 consecutive adult nephrotic syndrome cases.
    • Comparison of etiological and histological findings between elderly (≥60 years) and younger adult groups.
    • Assessment of treatment outcomes, specifically remission rates with prednisone.

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    Main Results:

    • Elderly patients constituted 25% of all adult cases.
    • Minimal change lesion was observed in 24% of elderly patients versus 16% in younger adults.
    • Membranous glomerulonephritis incidence was similar across age groups, while proliferative glomerulonephritis was less common in the elderly.
    • Four out of five elderly patients with minimal change disease achieved complete remission with prednisone.

    Conclusions:

    • Nephrotic syndrome is not as uncommon in the elderly as previously assumed.
    • Minimal change disease is a significant cause of nephrotic syndrome in older adults.
    • Elderly patients with nephrotic syndrome, particularly those with minimal change disease, can benefit from standard treatment protocols, including prednisone therapy.