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Thyrocalcitonin: stimulation of secretion by pentagastrin
Science (New York, N.Y.)
|June 18, 1971
Summary
Pentagastrin administration significantly boosts thyrocalcitonin secretion in pigs. This suggests gastrointestinal peptides like gastrin play a role in physiological thyrocalcitonin release.
Area of Science:
- Endocrinology
- Gastroenterology
- Physiology
Background:
- Thyrocalcitonin (TCT) is a hormone involved in calcium regulation.
- The role of gastrointestinal peptides in TCT secretion is not fully understood.
Purpose of the Study:
- To investigate the effect of pentagastrin on thyrocalcitonin secretion in pigs.
- To explore the potential role of gastrin in physiological thyrocalcitonin release.
Main Methods:
- Administration of a synthetic pentapeptide, pentagastrin, to pigs.
- Measurement of thyrocalcitonin levels following pentagastrin administration.
Main Results:
- A significant, rapid, and temporary increase in thyrocalcitonin secretion was observed.
- The effect was dose-dependent, with small doses eliciting a marked response.
Conclusions:
- Pentagastrin stimulates thyrocalcitonin secretion in pigs.
- Gastrointestinal peptides, such as gastrin, may be physiologically involved in regulating thyrocalcitonin release, particularly in response to stimuli like oral calcium administration.