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HLA-DW3 associated with coeliac disease
Lancet (London, England)
|March 6, 1976
Insights
Coeliac disease (C.D.) is strongly linked to the DW3 determinant, not primarily HLA-B8. This finding clarifies the genetic association in C.D. patients.
Area of Science:
- Immunogenetics
- Human Leukocyte Antigen (HLA) complex
- Gastroenterology
Background:
- Coeliac disease (C.D.) is an immune-mediated disorder triggered by gluten.
- Previous studies suggested a primary association between C.D. and HLA-B8.
- The genetic basis of C.D. requires further elucidation.
Purpose of the Study:
- To investigate the primary human leukocyte antigen (HLA) associations in coeliac disease (C.D.).
- To clarify the relationship between HLA-B8 and DW3 determinants in C.D. pathogenesis.
Main Methods:
- Human Leukocyte Antigen (HLA) typing for loci A, B, and D was performed on 28 coeliac disease patients.
- Multiple typing techniques were employed to ensure accurate HLA genotyping.
Main Results:
- Coeliac disease (C.D.) shows a primary association with the DW3 determinant.
- The association with HLA-B8 is secondary and likely due to linkage disequilibrium with DW3.
- Linkage disequilibrium between HLA-B8 and DW3 explains the previously observed HLA-B8 association.
Conclusions:
- The DW3 determinant is the primary genetic marker associated with coeliac disease (C.D.).
- The HLA-B8 association is secondary, explained by its linkage disequilibrium with DW3.
- Understanding these HLA associations provides insights into C.D. immunopathogenesis.
Abstract:
28 patients with coeliac disease (C.D.) were typed for the HLA-A, -B, and -D loci by several techniques. It was found that C.D. is primarily associated with the DW3 determinant and only secondarily with HLA-B8. The previously described association with HLA-B8 is explained by linkage disequilibrium between HLA-B8 and DW3.