Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Terminal transferase in human bone-marrow lymphocytes.

R D Barr, P S Sarin, S M Perry

    Lancet (London, England)
    |March 6, 1976
    PubMed
    Summary

    Terminal transferase (TdT) activity was found in normal human bone-marrow lymphocytes. These cells may be prothymocytes that can transform into acute lymphoblastic leukemia or chronic granulocytic leukemia.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Evolution of adolescent and young adult oncology in Canada.

    Current oncology (Toronto, Ont.)·2019
    Same author

    Health-related quality of life in long-term survivors of acute lymphoblastic leukemia in childhood and adolescence.

    Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2016
    Same author

    Accrual of adolescents and young adults with cancer to clinical trials.

    Current oncology (Toronto, Ont.)·2016
    Same author

    Nutritional status in children with cancer: Before, during and after therapy.

    Indian journal of cancer·2016
    Same author

    Measurement of socio-economic status in families of children with cancer in Guatemala.

    Pediatric blood & cancer·2014
    Same author

    A national study of the provision of oncology sperm banking services among Canadian fertility clinics.

    European journal of cancer care·2013

    Area of Science:

    • Hematology
    • Enzymology
    • Oncology

    Background:

    • Terminal transferase (TdT) is an enzyme.
    • Normal human bone-marrow lymphocytes are a focus of research.

    Purpose of the Study:

    • To investigate the localization of terminal transferase (TdT) activity in normal human bone-marrow lymphocytes.
    • To explore the potential role of these TdT-positive lymphocytes in leukemogenesis.

    Main Methods:

    • Enzyme activity assays.
    • Immunohistochemistry or flow cytometry to detect TdT in bone marrow cells.

    Main Results:

    • Terminal transferase (TdT) activity was successfully localized in normal human bone-marrow lymphocytes.
    • These lymphocytes may represent a prothymocyte population.

    Conclusions:

    • Normal human bone-marrow lymphocytes exhibit TdT activity.
    • These cells are potential precursors for acute lymphoblastic leukemia (ALL) and blastic phase chronic granulocytic leukemia (CGL).

    Related Experiment Videos