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Related Experiment Videos

Glaucomatocyclitic crisis.

C Raitta, A Vannas

    Archives of Ophthalmology (Chicago, Ill. : 1960)
    |April 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Glaucomatocyclitic crisis is associated with open-angle glaucoma. This long-term study found iris vascular changes and secondary atrophy, suggesting abnormal ciliary vascular reactivity contributes to attacks.

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    Area of Science:

    • Ophthalmology
    • Glaucoma Research
    • Vascular Biology

    Background:

    • Glaucomatocyclitic crisis, also known as Posner-Schlossman syndrome, is characterized by recurrent unilateral attacks of elevated intraocular pressure, ocular inflammation, and often mild anterior uveitis.
    • The association between glaucomatocyclitic crises and open-angle glaucoma has been suggested but requires further long-term investigation.
    • Understanding the underlying pathophysiology, particularly vascular changes, is crucial for managing this condition.

    Purpose of the Study:

    • To investigate the long-term association between glaucomatocyclitic crisis and open-angle glaucoma.
    • To characterize the vascular changes in the iris during and between acute attacks of glaucomatocyclitic crisis.
    • To explore the potential role of ciliary vascular system reactivity in the pathogenesis of glaucomatocyclitic crises.

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    Main Methods:

    • Longitudinal follow-up of ten patients diagnosed with glaucomatocyclitic crisis over a period exceeding ten years.
    • Clinical examinations including intraocular pressure measurement and assessment for glaucoma.
    • Iris angiography performed during the interval between attacks to evaluate vascular patterns.
    • Ophthalmoscopic examination during acute attacks to observe iris ischemia and post-attack changes.

    Main Results:

    • One patient was diagnosed with primary open-angle glaucoma, and two others showed suspicion for glaucoma, confirming a link between glaucomatocyclitic crisis and open-angle glaucoma.
    • During acute attacks, focal segmental iris ischemia was observed, followed by congestion, leakage, and hypotony in the post-attack phase.
    • Iris angiography between attacks revealed a rich vascular pattern, sometimes with tortuous vascular tufts, and secondary stromal and sphincter atrophy was noted.

    Conclusions:

    • The findings support a significant association between glaucomatocyclitic crises and the development of open-angle glaucoma.
    • Abnormal reactivity of the ciliary vascular system appears to play a role in the pathogenesis of acute glaucomatocyclitic attacks.
    • Iris vascular changes, including ischemia and secondary atrophy, are characteristic findings in patients with a history of glaucomatocyclitic crisis.