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6-thioguanine: antimitotic effect on human lymphocytes in vitro prevented by adenine
British Journal of Cancer
|March 1, 1971
Abstract:
The action of 6-thioguanine on the division of PHA-stimulated human lymphocytes in vitro has been investigated and shown to have a definite antimitotic effect which is prevented by adenine but not by guanine or hypoxanthine. It is suggested that in this test system 6-TG exerts its main inhibitory action on phosphoribosylpyrophosphate amidotransferase.