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Cyclic urinary leukopoietic activity in gray collie dogs
Science (New York, N.Y.)
|July 9, 1971
Summary
Urinary activity for bone marrow colony formation peaked during neutropenia in gray collies, suggesting a hormonal role in cyclic hematopoiesis. This activity was absent in normal dogs and undetectable once neutrophil counts normalized.
Area of Science:
- Hematology
- Endocrinology
- Veterinary Medicine
Background:
- Cyclic neutropenia is a rare condition characterized by periodic drops in neutrophil counts.
- Hematopoiesis, the process of blood cell formation, can be dysregulated in certain conditions.
- Understanding the regulatory mechanisms of hematopoiesis is crucial for developing potential therapies.
Purpose of the Study:
- To investigate the presence and pattern of urinary activity related to bone marrow colony formation in dogs with cyclic neutropenia.
- To explore a potential hormonal regulatory role for this urinary substance in the context of periodic hematopoiesis.
Main Methods:
- Collected consecutive 24-hour urine samples from two gray collies with cyclic neutropenia and two normal collies.
- Assayed urine samples for bone marrow colony-forming activity.
- Correlated urinary activity levels with blood neutrophil counts.
Main Results:
- Cyclic urinary activity for bone marrow colony formation was detected in gray collies.
- Peak activity coincided with the neutropenic phase, preceding neutrophil count recovery.
- Activity became undetectable when neutrophil counts returned to normal.
- Normal collies exhibited no detectable urinary activity.
Conclusions:
- The substance measured in urine appears to play a regulatory role in hematopoiesis.
- Findings suggest a potential hormonal influence on the periodic nature of cyclic neutropenia.
- This assay may help elucidate the complex mechanisms governing blood cell production.